Harvey J. Kliman, MD, PhD, is a physician scientist who specializes in studying and treating infertility and pregnancy complications, including recurrent pregnancy loss. He is also the director of the Reproductive and Placental Research Unit at Yale School of Medicine.
哈维·J·克利曼医学博士、哲学博士是一位医学科学家,专门研究和治疗不孕症和妊娠并发症,包括复发性流产。他同时也是耶鲁大学医学院生殖与胎盘研究中心主任。
“Much of my research focuses on the field of embryo implantation and what can go wrong in the process,” says Dr. Kliman, who developed the Endometrial Function Test®, which examines the uterine lining. “If the endometrium isn’t working correctly, a woman will not get pregnant.”
“我的研究主要集中在胚胎着床领域以及这一过程中可能出现的问题,”克莱曼博士说道。她研发了子宫内膜功能测试®,该测试用于检查子宫内膜。“如果子宫内膜功能异常,女性就无法怀孕。”
To use the test, a doctor takes a small sample of a woman’s endometrium (the mucous membrane lining the uterus) at two different times during her menstrual cycle. “The test tells us if we should give the patient more or less estrogen or progesterone before we transfer an embryo into her uterus,” Kliman explains. “Or sometimes we find inflammation, which we might need to treat.”
为了进行这项检测,医生会在女性月经周期的两个不同时间点,分别采集少量子宫内膜(子宫内壁的黏膜)样本。“这项检测可以告诉我们,在将胚胎移植到子宫之前,是否应该给患者增加或减少雌激素或孕激素的用量,”克利曼解释说。“有时我们还会发现炎症,这可能需要治疗。”
Dr. Kliman’s other research investigates pregnancy loss and recurrent pregnancy loss (the loss of two or more consecutive pregnancies). Dr. Kliman examines tissue samples from the placenta to understand why a loss happened.
克利曼博士的另一项研究方向是妊娠丢失和复发性妊娠丢失(连续两次或两次以上妊娠失败)。克利曼博士通过检查胎盘组织样本来了解妊娠丢失的原因。
“I will meet with the family and go through why they had their loss and what they can do the next time to hopefully prevent it,” he says. “Behind every healthy baby is a healthy placenta. The placenta is like the roots of a tree. The leaves and branches are the fetus. The tree trunk is the umbilical cord. If there aren't enough nutrients, if there's an infection, or if there's something developmentally wrong with that placenta, the roots don't grow normally and that can lead to problems.”
“我会与家属见面,了解他们失去孩子的原因,以及他们下次可以采取哪些措施来避免类似情况再次发生,”他说。“每个健康的宝宝背后都有一个健康的胎盘。胎盘就像树根,胎儿就像树叶和树枝,脐带就像树干。如果营养不足、发生感染,或者胎盘发育出现问题,胎盘根部就无法正常生长,这可能会导致各种问题。”
When it comes to working with families who have experienced pregnancy loss, Dr. Kliman says his first priority is to assure them it’s not their fault. “And if we can find a reason, we try to treat it,” he says. “I love helping patients. It’s amazing to help them overcome problems with implantation or a terrible loss, and see them achieve a successful pregnancy. I can't think of anything better.”
谈到帮助经历过流产的家庭,克莱曼医生说,他的首要任务是让他们相信这不是他们的错。“如果我们能找到原因,我们会尽力治疗,”他说。“我热爱帮助病人。能够帮助他们克服着床困难或可怕的流产,并见证他们成功怀孕,这感觉太棒了。我想不出还有什么比这更美好的事了。”









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