News | Sperm Quality Among U.S. Men: Potential Geographic Effects on Fertility



News | Sperm Quality Among U.S. Men: Potential Geographic Effects on Fertility

News | Sperm Quality Among U.S. Men: Potential Geographic Effects on Fertility


Study suggests geography may affect sperm quality, with lower measures in western and southern regions

A study published in The World Journal of Men’s Health found significant differences in sperm quality among men across six regions of the continental United States. Using mail-in sperm collection kits and semen analyses from 5,822 men, the study identified geographic differences in sperm concentration, motility, morphology, and other measures. The findings offer a new perspective on male infertility, particularly the potential role of geography.


Background: Male Infertility and Influencing Factors

About 8% to 12% of couples worldwide experience infertility, and male factors are involved in approximately 40% of cases. Semen analysis, including sperm count, concentration, motility, and morphology, is considered the best measure of male fertility. Age, body mass index, smoking and alcohol use, physical activity, education, stress, and certain medical conditions can affect sperm quality, but research suggests that geographic location may also have an influence.


Study Design and Methods

The study included 5,822 men who voluntarily requested semen analysis between 2019 and 2021. Participants came from six regions of the continental United States: Northeast, Southeast, Midwest, West, Pacific, and Southwest. None reported a history of male infertility. Researchers used validated at-home mail-in sperm collection kits. Participants collected semen samples at home and sent them by courier to a laboratory for analysis.


Results: Significant Regional Differences in Sperm Quality

Participants from the West had lower sperm concentration, total motile sperm count, and total motility than participants from other regions. Participants from the Southwest also had lower total sperm counts and progressive motility. In contrast, participants from the Midwest had higher total motile sperm counts and sperm motility, while those from the Northeast had higher sperm concentrations and total sperm counts.


When comparing participants younger than 35 with those aged 35 or older, the study found significant age-group differences in sperm concentration, total sperm count, motile sperm count, and progressive motility in the Northeast and Pacific regions. No such differences were observed in the Midwest.


The study also identified 1,654 participants with low sperm counts, or oligospermia, about 50% of whom were younger than 35. Although age did not significantly affect sperm quality overall, the prevalence of low sperm count was relatively higher in the Southwest and Southeast.


Significance and Conclusions

The study provides important data on the relationship between male fertility and geographic location. Sperm quality was notably higher among men in the Midwest and Northeast than among men in the Southwest and West. The study also found that the geographic association with sperm quality was independent of participant age and body mass index.


The researchers said the study offers a new direction for examining relationships among geography, social factors, and male fertility and may encourage consideration of regional differences in future male infertility care.


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