Knowledge | Study Confirms COVID-19 Boosters Do Not Increase Miscarriage Risk in Early Pregnancy
A study published in JAMA Network Open found that receiving a COVID-19 booster in early pregnancy does not increase the risk of miscarriage, adding further evidence supporting vaccination safety during pregnancy.
The study was conducted by the U.S. Centers for Disease Control and Prevention (CDC) Immunization Safety Office in collaboration with several large healthcare systems through the Vaccine Safety Datalink (VSD). Researchers analyzed more than 100,000 pregnancies at 6 to 19 weeks’ gestation across 8 health systems, focusing on whether a COVID-19 booster before 20 weeks was associated with miscarriage.
Results showed no increased miscarriage risk among pregnant patients who received a booster during the 28-day or 42-day observation windows. The researchers wrote: “The findings support the safety of COVID-19 booster vaccination in early pregnancy.”
This was an observational case-control surveillance study conducted from November 1, 2021, to June 12, 2022.
“COVID-19 infection during pregnancy increases the risk of adverse pregnancy outcomes, but many people who are pregnant or planning pregnancy remain hesitant to receive a booster because of vaccine safety concerns,” lead author Dr. Elyse Kharbanda, a senior research investigator at the HealthPartners Institute, said in a news release.
The University of Minnesota also noted: “Previous studies have shown that the initial COVID-19 vaccine series is safe during pregnancy and does not increase miscarriage risk. Multiple studies also show that COVID-19 infection may be more severe during pregnancy and may lead to worse maternal pregnancy outcomes.”
The findings provide healthcare professionals with additional evidence to recommend boosters to pregnant patients with greater confidence and may also help address public concerns.
Knowledge | Study Confirms COVID-19 Boosters Do Not Increase Miscarriage Risk in Early Pregnancy
Knowledge | Study Confirms COVID-19 Boosters Do Not Increase Miscarriage Risk in Early Pregnancy
A study published in JAMA Network Open found that receiving a COVID-19 booster in early pregnancy does not increase the risk of miscarriage, adding further evidence supporting vaccination safety during pregnancy.
The study was conducted by the U.S. Centers for Disease Control and Prevention (CDC) Immunization Safety Office in collaboration with several large healthcare systems through the Vaccine Safety Datalink (VSD). Researchers analyzed more than 100,000 pregnancies at 6 to 19 weeks’ gestation across 8 health systems, focusing on whether a COVID-19 booster before 20 weeks was associated with miscarriage.
Results showed no increased miscarriage risk among pregnant patients who received a booster during the 28-day or 42-day observation windows. The researchers wrote: “The findings support the safety of COVID-19 booster vaccination in early pregnancy.”
This was an observational case-control surveillance study conducted from November 1, 2021, to June 12, 2022.
“COVID-19 infection during pregnancy increases the risk of adverse pregnancy outcomes, but many people who are pregnant or planning pregnancy remain hesitant to receive a booster because of vaccine safety concerns,” lead author Dr. Elyse Kharbanda, a senior research investigator at the HealthPartners Institute, said in a news release.
The University of Minnesota also noted: “Previous studies have shown that the initial COVID-19 vaccine series is safe during pregnancy and does not increase miscarriage risk. Multiple studies also show that COVID-19 infection may be more severe during pregnancy and may lead to worse maternal pregnancy outcomes.”
The findings provide healthcare professionals with additional evidence to recommend boosters to pregnant patients with greater confidence and may also help address public concerns.
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