Dr. Panayota Napoleon Zarmakoupis, United States
     
4.1
Consultations 39
Reproductive Medicine
Doctor Introduction

Dr. Panayota Napoleon Zarmakoupis, United States


Panayota N. Zarmakoupis, MD, is a fertility specialist at Reproductive Medicine Associates (RMA) in Lake Mary, Florida. Dr. Zarmakoupis is double board-certified in obstetrics and gynecology and reproductive endocrinology and infertility (REI). She attended the National and Kapodistrian University of Athens School of Medicine in Greece and is licensed to practice in the United States, Greece, and the United Arab Emirates (UAE).

Specializing in REI allows Dr. Zarmakoupis to combine her interests in the endocrine system, genetics, and surgery. She is fascinated by the field’s collaborative and complex nature. Above all, she considers caring for people during their most vulnerable and emotional moments her true calling. “To this day, I consider it an honor that patients trust me during their infertility journey,” she says.

After medical school, Dr. Zarmakoupis completed her residency at NYU Langone Hospital in Mineola, New York, where she served as chief resident, followed by an REI fellowship at the University of South Florida in Tampa. Her experience includes serving as medical director of several OB/GYN and REI practices, and she is passionate about global health and teaching. She also pioneered several firsts in the field, including offering preimplantation genetic testing for aneuploidy (PGT-A) and family balancing. Her clinical interests include efficient infertility care, poor response to in vitro fertilization (IVF), recurrent implantation failure, PGT-A, and preimplantation genetic testing for monogenic disorders (PGT-M).

This made joining IVI RMA, a global leader in reproductive medicine, an easy decision. “At RMA, I can participate in groundbreaking research and see that knowledge applied in clinical practice. RMA’s culture of continual learning and adapting to new discoveries also keeps my work dynamic and stimulating,” says Dr. Zarmakoupis. “Most importantly, my patients benefit from exceptional embryology support, which contributes to such high success rates. I knew RMA’s commitment to excellence and innovation would be professionally rewarding.”

Dr. Zarmakoupis is equally committed to connecting with her patients. She creates a safe space for them to share their feelings, helps them make informed decisions, and actively involves them in their care. Having treated patients from around the world, she draws on her strong cultural awareness to ensure that each person receives a personalized treatment plan reflecting their unique needs, beliefs, and goals.

Outside the office, Dr. Zarmakoupis treasures time with her two daughters. She also enjoys music and traveling abroad to explore new cultures. She has combined vacations to places such as sub-Saharan Africa with volunteer work to raise awareness of infertility. Her childhood in Greece fostered a love of swimming, and she also enjoys hiking. A trip to Namibia, ballroom dancing lessons, and seeing the opera Cavalleria Rusticana at the Dr. Phillips Center for the Performing Arts in Orlando are all on her wish list.


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Location and Hours
400 Colonial Center Pkwy #150, Lake Mary, FL 32746, United States
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  • Monday

    06: 00 - 16: 30

  • Tuesday

    06: 00 - 16: 30

  • Wednesday

    06: 00 - 16: 30

  • Thursday

    06: 00 - 16: 30

  • Friday

    06: 00 - 16: 30

  • Saturday

    06: 00 - 10: 00

  • Sunday

    06: 00 - 10: 00

  • Closed Now
    Affiliated Clinics
    RMA Florida | Lake Mary, United States
         
    • Reproductive Medicine
    Hours: 06: 00 - 16: 30
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    Featured Reviews
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    Apr 3, 2025
    I completed my first round of IVF through RMA, and it went very well. The nurses and doctors were caring and answered all my questions.
    Apr 2, 2025
    They answered every question I had about the procedure knowledgeably, professionally, and kindly. They also took my calls when I had questions. I am deeply grateful that they gave me this opportunity and will always appreciate them.
    Mar 4, 2025
    I cannot say enough good things about RMA! I am currently 23 weeks pregnant with my rainbow IUI baby. The entire front desk staff, nurses, PA Roma, and Dr. P were wonderful. We felt everyone genuinely cared about our experience and was invested in our fertility journey. I especially want to thank our PA, Roma Benfanti, who supported us throughout. She explained everything, made us feel comfortable, and clearly cares deeply about her patients!
    Mar 2, 2025
    I will never return here.
    Jan 14, 2025
    I am writing to express my dissatisfaction with my recent experience scheduling an appointment at your fertility clinic in Lake Mary, Florida. I requested a medical consultation, and my husband and I were instructed to download an app and complete 14 pages of personal and medical information before you would verify whether you accepted my insurance, BCBS. It seemed unusual that you could not confirm acceptance of such common insurance without requiring patients to complete this lengthy process. I completed all required information and waited two weeks for an update about my insurance. The only missing item was a signature on a DocuSign document. Despite having all our contact information, including phone numbers and email addresses, you then canceled our appointment without notice. This cost us valuable time, which is especially important for people facing fertility-related health concerns. Throughout the process, I was also unable to confirm whether you accepted my insurance. I was repeatedly transferred to billing, where no one responded. I found this process unreasonable and frustrating. Your clinic appears to prioritize collecting personal data over providing efficient and compassionate patient care. I request an explanation of what happened and improvements to prevent other patients from having the same experience. I look forward to your prompt response to resolve this issue and prevent future negative experiences.
    May 22, 2025
    Sep 21, 2025
    At 8 a.m. on Sunday, we traveled a long distance to the clinic according to the schedule posted here. No one was there; the office was empty and closed. We call every day, but they do not provide us with service.
    Oct 7, 2025
    Oct 28, 2025
    We have been coming here for nearly two years. Thanks to your help, we have this sweet little boy in our lives. He turned one a month ago. Thank you to everyone, especially Roma. She listened and helped when we felt we could not keep going. I hope she is still there because we plan to return when we are ready!
    Oct 21, 2025
    This place has nothing but incompetent staff. My first appointment with the nurse practitioner was a completely misleading consultation. I asked whether bloodwork was included in the HSG fee, and she said yes. It turned out the HSG alone cost $800. No HSG costs $800 by itself except at a predatory clinic like this. I later learned that half of what these people said was wrong. I practically had to beg them to call in or mail my medication. This place is exhausting. The staff are lazy and incompetent. I would never waste my time or hard-earned money at this clinic.
    Dec 3, 2025
    This clinic has steadily declined since Dr. P and his team left RMA. No one answers the phone or the billing line, and I had to send documents five times before they were received. Search online for Dr. P's current location and go directly to his clinic to avoid dealing with RMA.
    Dec 2, 2025
    The nurses here are wonderful, but everything else about our experience was terrible. Our egg retrieval was canceled two months in a row because the doctor overlooked our medical records. We have now decided to use another clinic, but after more than two months, we still have not received the money back for the canceled cycles. They owe us more than $15,000. Our financial coordinator ignores us, and no one can give us a definite answer about when we will receive the refund. I would give 0 stars if I could.
    Dec 2, 2025
    They do not even answer the phone.
    Dec 27, 2025
    My gestational carrier and I have consistently used this clinic for pregnancy monitoring. We checked the holiday hours online and scheduled her for laboratory testing first thing on December 26. Beginning at 2:30 p.m., we repeatedly called to have the results sent to our fertility center, but RMA Florida's phones were turned off. Although the clinic was supposed to remain open until 4:30 p.m., we could not reach anyone. Given the time-sensitive nature of these results, this was unacceptable.
    Dec 9, 2025
    My first high-risk pregnancy visit was at this hospital. This is my second high-risk pregnancy because I have a cerebral aneurysm. My last pregnancy, just over a year ago, was managed at Orlando Health. I transferred to AdventHealth hoping for better care because of their experience and because I had safely delivered my daughter at AdventHealth Orlando in August 2024. However, the experience was terrible, from scheduling through the visit. Dr. Ahmed M Al-Malt in particular was arrogant and rude. He questioned my age and asked why I was having another child. He also challenged my choices regarding treatment for the aneurysm. In front of my 12-year-old daughter, he told me I might die without treatment, as though I did not already know. He was clearly unprepared for my visit and had not reviewed the section of my record concerning the aneurysm. He knew nothing about my genetic testing or blood results and instead asked me what the results were. He spent only 10 minutes with me and showed no concern when I reported severe pain on my left side. I was worried I might have a urinary tract infection. He said it could be nerve compression or a UTI but offered no help. He did not even suggest being evaluated by an OB-GYN in the same clinic. His attitude and lack of concern for my health and my unborn baby's health deeply disappointed my family and me. I would never recommend this doctor. Please research carefully—your life and your unborn baby's life are at stake. I decided to transfer my care back to Dr. Christopher Dixon at Orlando Health, directly across the street.
    Jan 21, 2026
    Despite some recent reviews, my experience with this clinic has always been good. The staff and doctors are very helpful and kind. Although my original doctor left the practice, my treatment has remained consistent with no delays. Their nurse Amanda is wonderful, and the nurses always return my calls promptly when I have questions or concerns. I appreciate their evidence-based approach to fertility treatment. So far, everything is progressing well after my first transfer.
    Apr 19, 2026
    I would greatly advise against going to this place for your fertility needs. I paid both a deposit and a large fee to even go to an initial appointment. While I was advised of some additional costs, there were costs that were not discussed with me and I was later billed for and they were exponential. This came as an huge surprise to me as I was obviously not expecting it. Additionally, they tested me for things I noted I had already been tested for and could’ve also avoided that cost. My husband went for his appointment, paid cash in full amount and was then later billed this amount again in a mail statement. I was also billed a fee for blood draw, which I guess is not included in the large amount you pay for your initial appointment. The medical assistant who took my blood also greatly bruised me beyond a normal bruising for a blood draw. As a medical assistant and someone working in healthcare I know what that looks like. It appears their organization with financials is also lacking. About a month or so after my appointment it was determined I could no longer move forward with fertility treatment because unfortunately I have been diagnosed cancer and I received a surprise $35 billing request to get my records that I personally never even requested. While the staff appeared nice at my one and only appointment I am disappointed in the organization as a whole. They seem money hungry and don’t really truly care for their patients.
    Apr 17, 2026
    Best team ever!!
    May 26, 2026
    马森医生和全体员工都非常棒!我一进门就感到很放松和受欢迎。他们非常专业,知识渊博!

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    • Many years of experience
    • English
    • National and Kapodistria University of Athens
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    • Clinic Address
      400 Colonial Center Pkwy #150, Lake Mary, FL 32746, United States

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    • Preimplantation Genetic Testing and IVF
      Donor Egg or Sperm IVF
      Third-Party Reproduction Information (Subject to Local Law)
      Other