Piedmont Reproductive Endocrinology Group - Greenville, United States
     
4.3
Consultations 51
Reproductive Medicine
Hours: 07: 30 - 16: 30
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Clinic Details

Thoughtful, Personalized Fertility Care.

We are PREG, the largest network of fertility centers in the Carolinas, and we have been helping build families for more than 20 years.

 

Whether you are a couple trying to conceive, an individual seeking to start a family, a member of the LGBTQ community, or not yet ready for parenthood but interested in exploring future fertility options, we are here for you. Our patient-centered approach ensures that we meet you where you are.


Listing Highlights

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Location and Hours
17 Caledon Ct # C, Greenville, SC 29615, United States
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  • Monday

    07: 30 - 16: 30

  • Tuesday

    07: 30 - 16: 30

  • Wednesday

    07: 30 - 16: 30

  • Thursday

    07: 30 - 16: 30

  • Friday

    07: 30 - 12: 00

  • Saturday

    Closed

  • Sunday

    Closed

    • Closed Now
    Facilities and More
    • Credit cards accepted
    Doctors at This Clinic
    Dr. John Nichols, United States
         

    Reproductive Medicine |

    Many years of experience | Consultations 46

    Female infertilityMale infertility
    4.6

    Free Consultation
    Dr. John Payne, United States
        

    Reproductive Medicine |

    Many years of experience | Consultations 69

    Female infertilityMale infertility
    4.0

    Free Consultation
    Dr. Travis McCoy, United States
        

    Reproductive Medicine |

    Many years of experience | Consultations 65

    Female infertilityMale infertility
    4.2

    Free Consultation
    Dr. Edward Tarnawa, United States
        

    Reproductive Medicine |

    Many years of experience | Consultations 48

    Female infertilityMale infertility
    3.8

    Free Consultation
    Dr. Kathryn Imgrund, United States
        

    Reproductive Medicine |

    Many years of experience | Consultations 56

    Female infertilityMale infertility
    4.1

    Free Consultation
    Dr. Graham Theisen, United States
        

    Reproductive Medicine |

    Many years of experience | Consultations 52

    Female infertilityMale infertility
    4.4

    Free Consultation
    Featured Reviews
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    Review Piedmont Reproductive Endocrinology Group - Greenville, United States
    On-Site Overall Rating

    37 ratings

    • 5 stars
    • 4 stars
    • 3 stars
    • 2 stars
    • 1 stars
    Jun 24, 2026
    So to start the entire procedure and testing is awkward and vulnerable for a man. No one wants to do what you do here but the staff so polite and respectful and reassuring and most importantly professional when it comes to the task at hand. From the front desk to the lady in the back Mrs. Alyssa the entire group of people are so kind and understanding , they don’t rush you they get to the point and let you go to work literally lol. The room is very private they give you everything and more that you need and when it’s over they explain everything in understandable terms. I praise the lord my test came back in good health and the report was direct and explained everything to me in terms I could understand. My wife and I will definitely use them again and recommended them to everyone.
    Apr 21, 2026
    May 8, 2026
    After 15 years of prayer, hope, and multiple miscarriages, God blessed us with our miracle baby in April. We are deeply grateful to the Piedmont Reproductive Medicine team in Greenville for walking this journey with us. Special thanks to my nurse Kristina for her constant support and care; Jackie in the lab for her kindness and encouragement; and Dr. Payne for his wise guidance and attentive care at every step. We wanted to give up many times, but God had a greater plan and worked through this exceptional team to bring our precious baby into the world. We will always be grateful for the love, hope, and guidance we received. 💙 “He has made everything beautiful in its time.” — Ecclesiastes 3:
    Mar 10, 2026
    I cannot say enough good things about PREG! They are always willing to answer questions, respond quickly to emails, and are both professional and friendly.
    Mar 19, 2026
    Dr. Payne, Dr. McCoy, and Chloe were absolutely amazing! I have never felt so much support during such an emotional time in my life. Strongly recommend!
    Mar 25, 2026
    I cannot say enough good things about this fertility clinic. From the moment you enter, you are treated with kindness, compassion, and respect. The doctors are highly knowledgeable, listen carefully to your concerns, explain everything clearly, and make you feel comfortable and reassured throughout treatment. The nurses are also wonderful—caring, patient, always willing to answer questions, and comforting during what can be an emotional journey. Every staff member goes above and beyond to ensure you are cared for at each step. The front desk team also deserves special recognition. They are always warm, friendly, and helpful, whether scheduling appointments or answering questions. They create a positive experience from the moment you arrive. Everyone at the clinic works together to create such a supportive and encouraging environment. You can tell they genuinely care about every patient and want the best possible outcome. I am deeply grateful for everyone's dedication, professionalism, and compassion. I highly recommend this clinic to anyone on a fertility journey.
    Mar 25, 2026
    Mar 25, 2026
    Nov 21, 2025
    Nov 22, 2025
    Exceptional medical care and a truly life-changing experience. Every step, from the first consultation through the final stage of treatment, reflected professionalism and compassion. Our doctor, Dr. Payne, was outstanding and guided us throughout. Nurses Madison, Christina, and Chandler were equally amazing. The entire PREG team made the process easy and positive. The clinic is professional, efficient, and respectful of patients' time and feelings. Appointments were punctual, communication was clear, and we always felt supported. We wholeheartedly recommend PREG to anyone seeking truly exceptional fertility treatment.
    Oct 17, 2025
    Kelsey was very helpful and patient.
    Oct 21, 2025
    My experience at PREG was wonderful! Dr. McCoy was my primary reproductive endocrinologist. At my first visit, he identified a suspected cause of my infertility and confirmed it with testing. He then presented several treatment options and thoroughly explained the benefits and risks of each. We never felt pressured to choose any particular option. During treatment at PREG, I occasionally saw other doctors for procedures, and they were all excellent. The nursing care was flawless; the nurses were compassionate and happy to address my questions and concerns. My primary nurse, Kristina, was outstanding and very patient, especially in easing my anxiety, as I am naturally anxious. She always addressed or communicated my concerns quickly, and every interaction I had with staff was positive. I highly recommend PREG to anyone struggling with infertility or recurrent pregnancy loss!
    Oct 25, 2025
    I had an excellent experience at PREG Greenville. I highly recommend them! Nurse Chloe is the best.
    Oct 25, 2025
    I only needed a blood draw, but Melissa was wonderful.
    Nov 4, 2025
    Every nurse and doctor I met was helpful and thoughtful! I am very pleased with everything they have done for me and my unborn baby. Dr. Payne is my primary doctor, and he is wonderful!
    Oct 10, 2025
    I do not usually leave reviews, but the care I received at PREG was so exceptional that I had to. The team truly goes above and beyond. Chloe is the nurse everyone needs in their life. She is kind, funny, and incredibly helpful—she made every visit feel easy and stress-free. As Gypsy Rose once said, ‘Things are not always what they seem.’ This time, they seemed great—and they truly were. I met with Dr. Payne—do not worry, the name is misleading—and he was thoughtful and made me feel completely at ease. The entire PREG team is wonderful, but Chloe stands out. 10/10, I would trust her with my uterus again.
    Oct 10, 2025
    Love PREG!! Nurse Chloe and Maddie went above and beyond to answer all my questions about my first pregnancy and made me feel very comfortable.
    Oct 13, 2025
    This place is the best place to come. They listen to you and try to accommodate your needs and hold your hand through the process
    Oct 13, 2025
    The staff is amazing. They are really nice and helpful.
    Oct 13, 2025
    Jacqueline in bloodwork is always so cheerful and great at her job. Everyone here is very responsive especially the ivf team
    Sep 4, 2025
    Today, at nearly 9 weeks pregnant, we finally graduated from PREG. The PREG nurses truly care, are always ready to answer questions, calm your nerves, and guide you through the process or next steps. They always smile, take plenty of time to answer questions, and gladly accommodate requests. The PREG nurses are amazing!
    Aug 5, 2025
    We are incredibly grateful for the attentive care we received at PREG Greenville. From day one, we genuinely felt the warmth of the PREG family, from Ms. Jackie drawing my blood to the compassionate and professional care provided by Dr. McCoy, Dr. Nichols, and Dr. Payne. Every staff member was welcoming and gave us continual encouragement throughout the process. Our transfer nurse Kristina was especially outstanding. She supported me throughout, was always available to answer my questions, and provided comfort when I needed it most. On graduation day, I could not hold back my tears, not only from the immense gratitude and joy of their helping us create our miracle, but also from sadness knowing we would not see this wonderful team again for a while. I highly recommend PREG to anyone beginning a fertility journey. Thanks to them, I am pregnant with our precious baby, and we will always be grateful for their care and support. ❤️
    Aug 26, 2025
    My wife and I will always be grateful to this clinic! Dr. Payne, the nurses, and staff were amazing and very helpful, and they always answered promptly whenever I had questions! Thank you, PREG Greenville, for giving us our beautiful miracle! We will definitely return in the future.
    Aug 26, 2025
    My husband and I are very grateful to PREG Greenville, especially Dr. Payne, for the wonderful experience she provided. As older prospective parents, we had previously been told at another clinic that IVF using my own eggs had a success rate below 10%. We went to PREG to discuss embryo transfer, but after testing, Dr. Payne was very confident that ‘we could succeed.’ We decided to try conventional IVF. We completed one retrieval, obtained one embryo, and transferred it using a carefully designed protocol. With only one chance, it would have been easy to feel discouraged, but Dr. Payne remained positive throughout treatment. Every member of the PREG care team was responsive, knowledgeable, and treated us like family. At every step, they gave us hope to continue. Today, we visited PREG Greenville to introduce Dr. Payne and the staff to our only child, who was destined to complete our family. I am deeply grateful for our baby girl, who would not be with us today without Dr. Payne and the PREG Greenville staff.
    Jun 5, 2025
    What a wonderful group of people who genuinely care about us! We became pregnant on our first IVF attempt. God truly worked through the Greenville clinic!
    Jun 10, 2025
    When I went to a fertility clinic with an infertility diagnosis, I did not know what to expect, but I found a fertility team that was extremely thorough with testing and diagnosis. Their solutions were reassuring and encouraging and helped me keep moving forward. They truly helped me through one of the scariest times of my life. Dr. Nichols is amazing; I would not be here without him. He was honest and direct and gave us the best options. With his help and that of the wonderful nurses and staff, we are now expecting a miracle baby. I did not know if it was possible, but with their help, we succeeded. I recommend them to anyone experiencing infertility. My husband and I are deeply grateful.
    Jun 24, 2025
    Dr. Payne is the best! I cannot say enough good things about the Greenville clinic. The entire staff is wonderful!
    Jul 19, 2025
    Dr. Payne and his nurse Tara are amazing! They are thorough and attentive in their work. Lindsay answered all my questions and offered advice. I highly recommend this excellent team. Miracles really do happen, thanks to them!
    Aug 3, 2025
    I cannot thank PREG enough for all they have done to help support me through my fertility journey! I am now 8 weeks pregnant thanks to them and have my last ultrasound appointment with them on Monday. Madison Browning and Dr. Payne have been so great through out this entire experience and I HIGHLY recommend them for all your fertility needs :) The best part of PREG is the communication they give to their patients, I called or messaged with any questions I ever had and they almost immediately got back to me every time. They are so great here I almost wish they could be my OB lol. Also Mrs. Jackie is the best lady for your labwork, she’s hilarious and always calls for an ice pack when you need it (for my case every time).
    Apr 9, 2025
    I tried to make an appointment in Spanish, but no one wanted to help me. I waited 30 minutes and nothing happened. They told me to call and said they would return my call. I have been calling for three weeks. I feel discriminated against because I do not speak English. I use a translator, but they still did not want to help me schedule an appointment. I tried to make an appointment in Spanish, but no one wanted to help me. I waited 30 minutes and nothing happened. They told me to call and said they would return my call. I have been calling for three weeks. I feel discriminated against because I do not speak English. I used a translator, but even then they did not want to help me make an appointment.
    Apr 25, 2025
    May 8, 2025
    We had a wonderful experience at PREG Greenville! We appreciate the hard work of Dr. Payne, the embryologists, and our IVF coordinator, the nurses' care and compassion, and the front desk staff's patience with all our questions! We highly recommend their team to anyone experiencing infertility!
    Dec 12, 2024
    I had the best experience. Dr. Nichols and the staff are second to none. They are all intelligent, kind, efficient, and not driven by profit. PREG is the only real choice in the Upstate. I am a doctor, and I know. ❤️‍🔥 Get to PREG as soon as possible.
    Feb 23, 2025
    They are a highly professional and knowledgeable team. I am a patient of Dr. Payne, and he is the best. He truly cares for his patients, listens carefully, and follows through on diagnosis so the problem can be addressed. For a better outcome, this team truly knows what it is doing.
    Mar 2, 2025
    On January 29, 2025, I had an initial appointment with Dr. Nichols at the fertility clinic called PREG in West Columbia, South Carolina. I filed an assault complaint with the City of West Columbia, South Carolina, because during my examination he wore one glove to hold the ultrasound probe while his left, ungloved hand was unclean. While I was in the stirrups, he used that unclean hand and touched my clitoris while inserting the probe. He completed the examination, smelled his finger, and left the examination room with the door open. While the nurse finished the examination, my buttocks were exposed to anyone walking past.
    Mar 13, 2025
    Dr. John Payne is wonderful! I am extremely pleased with the staff and Dr. Payne. We highly recommend PREG :)
    Mar 25, 2025
    They deserve negative stars. Run from this clinic! Two years ago, I saw Dr. Payne for a consultation. I was told I could never have children and needed a hysterectomy as soon as possible. He then gave me the options of using donor eggs or a surrogate. When I said those were not options for me, he replied, "If you wanted a child badly enough, you would change your mind." I do not know who in their right mind would say that to anyone. Thank God I sought a second opinion, because I am now sitting here holding my healthy one-week-old baby, conceived with my own egg. Always seek a second opinion, and never go here or believe a word Dr. Payne says. If I had listened to him, I would not have my perfect baby boy!

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    • 6 doctors
    • Operating for many years
    • PGT IVF
    • +1 8642327734
    • pregonline.com
    • Clinic Address
      17 Caledon Ct # C, Greenville, SC 29615, United States

    CDC Success Rates

    Data source: U.S. CDC 2022 Annual ART Report (cumulative live birth rate; new patients across all intended retrievals; own-egg cycles only)

    • Annual Cycles

      605

    • U.S. Median

      511

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