Piedmont Reproductive Endocrinology Group - Greenville, United States
4.3
Consultations 51
Reproductive Medicine
Hours: 07: 30 - 16: 30
Clinic Details
Thoughtful, Personalized Fertility Care.
We are PREG, the largest network of fertility centers in the Carolinas, and we have been helping build families for more than 20 years.
Whether you are a couple trying to conceive, an individual seeking to start a family, a member of the LGBTQ community, or not yet ready for parenthood but interested in exploring future fertility options, we are here for you. Our patient-centered approach ensures that we meet you where you are.
Listing Highlights
Free estimate
Photos and Videos
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Location and Hours
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Monday
07: 30 - 16: 30
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Tuesday
07: 30 - 16: 30
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Wednesday
07: 30 - 16: 30
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Thursday
07: 30 - 16: 30
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Friday
07: 30 - 12: 00
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Saturday
Closed
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Sunday
Closed
- Open Now
Facilities and More
Credit cards accepted
Doctors at This Clinic
Reproductive Medicine |
Many years of experience | Consultations 48
Female infertilityMale infertility
Reproductive Medicine |
Many years of experience | Consultations 69
Female infertilityMale infertility
Reproductive Medicine |
Many years of experience | Consultations 56
Female infertilityMale infertility
Reproductive Medicine |
Many years of experience | Consultations 65
Female infertilityMale infertility
Reproductive Medicine |
Many years of experience | Consultations 52
Female infertilityMale infertility
Reproductive Medicine |
Many years of experience | Consultations 46
Female infertilityMale infertility
Featured Reviews
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Reviews are for reference only. Consider official information and professional advice independently.
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Review
Piedmont Reproductive Endocrinology Group - Greenville, United States
On-Site Overall Rating
37 ratings
- 5 stars
- 4 stars
- 3 stars
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Curry Reeves
2 months ago
Jun 24, 2026
The entire procedure and testing process is awkward and vulnerable for a man. No one wants to do what you have to do here, but the staff are polite, respectful, reassuring, and, most importantly, professional. Everyone, from the front desk staff to Ms. Alyssa in the back, is kind and understanding. They do not rush you; they get to the point and let you get back to work, literally. The room is very private, they provide everything you need and more, and afterward they explain everything in clear terms. I praise the Lord that my test results were healthy. The report was straightforward and explained everything in language I could understand. My wife and I would definitely use their services again and recommend them to everyone.
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Erica Brooke
4 months ago
May 8, 2026
After 15 years of prayer, hope, and multiple miscarriages, God blessed us with our miracle baby in April. We are deeply grateful to the Piedmont Reproductive Medicine team in Greenville for walking this journey with us.
Special thanks to my nurse Kristina for her constant support and care; Jackie in the lab for her kindness and encouragement; and Dr. Payne for his wise guidance and attentive care at every step.
We wanted to give up many times, but God had a greater plan and worked through this exceptional team to bring our precious baby into the world. We will always be grateful for the love, hope, and guidance we received. 💙 “He has made everything beautiful in its time.” — Ecclesiastes 3:
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Amber Boggs
6 months ago
Mar 10, 2026
I cannot say enough good things about PREG! They are always willing to answer questions, respond quickly to emails, and are both professional and friendly.
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Cheyenne Gowan
6 months ago
Mar 19, 2026
Dr. Payne, Dr. McCoy, and Chloe were absolutely amazing! I have never felt so much support during such an emotional time in my life. Strongly recommend!
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Brittany Rae Cimino
5 months ago
Mar 25, 2026
I cannot say enough good things about this fertility clinic. From the moment you enter, you are treated with kindness, compassion, and respect. The doctors are highly knowledgeable, listen carefully to your concerns, explain everything clearly, and make you feel comfortable and reassured throughout treatment.
The nurses are also wonderful—caring, patient, always willing to answer questions, and comforting during what can be an emotional journey. Every staff member goes above and beyond to ensure you are cared for at each step.
The front desk team also deserves special recognition. They are always warm, friendly, and helpful, whether scheduling appointments or answering questions. They create a positive experience from the moment you arrive.
Everyone at the clinic works together to create such a supportive and encouraging environment. You can tell they genuinely care about every patient and want the best possible outcome. I am deeply grateful for everyone's dedication, professionalism, and compassion. I highly recommend this clinic to anyone on a fertility journey.
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Karthik Peddireddy
9 months ago
Nov 22, 2025
Exceptional medical care and a truly life-changing experience. Every step, from the first consultation through the final stage of treatment, reflected professionalism and compassion.
Our doctor, Dr. Payne, was outstanding and guided us throughout. Nurses Madison, Christina, and Chandler were equally amazing.
The entire PREG team made the process easy and positive. The clinic is professional, efficient, and respectful of patients' time and feelings. Appointments were punctual, communication was clear, and we always felt supported. We wholeheartedly recommend PREG to anyone seeking truly exceptional fertility treatment.
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Marina Osborn
11 months ago
Oct 21, 2025
My experience at PREG was wonderful! Dr. McCoy was my primary reproductive endocrinologist. At my first visit, he identified a suspected cause of my infertility and confirmed it with testing. He then presented several treatment options and thoroughly explained the benefits and risks of each. We never felt pressured to choose any particular option. During treatment at PREG, I occasionally saw other doctors for procedures, and they were all excellent. The nursing care was flawless; the nurses were compassionate and happy to address my questions and concerns. My primary nurse, Kristina, was outstanding and very patient, especially in easing my anxiety, as I am naturally anxious. She always addressed or communicated my concerns quickly, and every interaction I had with staff was positive. I highly recommend PREG to anyone struggling with infertility or recurrent pregnancy loss!
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Sarah Mobley
10 months ago
Oct 25, 2025
I had an excellent experience at PREG Greenville. I highly recommend them! Nurse Chloe is the best.
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Meggan Gambrell
10 months ago
Nov 4, 2025
Every nurse and doctor I met was helpful and thoughtful! I am very pleased with everything they have done for me and my unborn baby. Dr. Payne is my primary doctor, and he is wonderful!
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Molly Pabst
11 months ago
Oct 10, 2025
I do not usually leave reviews, but the care I received at PREG was so exceptional that I had to. The team truly goes above and beyond.
Chloe is the nurse everyone needs in their life. She is kind, funny, and incredibly helpful—she made every visit feel easy and stress-free. As Gypsy Rose once said, ‘Things are not always what they seem.’ This time, they seemed great—and they truly were.
I met with Dr. Payne—do not worry, the name is misleading—and he was thoughtful and made me feel completely at ease.
The entire PREG team is wonderful, but Chloe stands out. 10/10, I would trust her with my uterus again.
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Anna Brewington
11 months ago
Oct 10, 2025
Love PREG!! Nurse Chloe and Maddie went above and beyond to answer all my questions about my first pregnancy and made me feel very comfortable.
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Aubrey Horne
11 months ago
Oct 13, 2025
This place is the best place to come. They listen to you and try to accommodate your needs and hold your hand through the process
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chrystal constant
11 months ago
Oct 13, 2025
Jacqueline in bloodwork is always so cheerful and great at her job. Everyone here is very responsive especially the ivf team
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Emily Hulse
12 months ago
Sep 4, 2025
Today, at nearly 9 weeks pregnant, we finally graduated from PREG. The PREG nurses truly care, are always ready to answer questions, calm your nerves, and guide you through the process or next steps. They always smile, take plenty of time to answer questions, and gladly accommodate requests. The PREG nurses are amazing!
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Madison
1 year ago
Aug 5, 2025
We are incredibly grateful for the attentive care we received at PREG Greenville. From day one, we genuinely felt the warmth of the PREG family, from Ms. Jackie drawing my blood to the compassionate and professional care provided by Dr. McCoy, Dr. Nichols, and Dr. Payne. Every staff member was welcoming and gave us continual encouragement throughout the process.
Our transfer nurse Kristina was especially outstanding. She supported me throughout, was always available to answer my questions, and provided comfort when I needed it most.
On graduation day, I could not hold back my tears, not only from the immense gratitude and joy of their helping us create our miracle, but also from sadness knowing we would not see this wonderful team again for a while.
I highly recommend PREG to anyone beginning a fertility journey. Thanks to them, I am pregnant with our precious baby, and we will always be grateful for their care and support. ❤️
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Denia Brean
1 year ago
Aug 26, 2025
My wife and I will always be grateful to this clinic! Dr. Payne, the nurses, and staff were amazing and very helpful, and they always answered promptly whenever I had questions! Thank you, PREG Greenville, for giving us our beautiful miracle! We will definitely return in the future.
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Jamie Chamberlin
1 year ago
Aug 26, 2025
My husband and I are very grateful to PREG Greenville, especially Dr. Payne, for the wonderful experience she provided. As older prospective parents, we had previously been told at another clinic that IVF using my own eggs had a success rate below 10%. We went to PREG to discuss embryo transfer, but after testing, Dr. Payne was very confident that ‘we could succeed.’ We decided to try conventional IVF. We completed one retrieval, obtained one embryo, and transferred it using a carefully designed protocol. With only one chance, it would have been easy to feel discouraged, but Dr. Payne remained positive throughout treatment. Every member of the PREG care team was responsive, knowledgeable, and treated us like family. At every step, they gave us hope to continue. Today, we visited PREG Greenville to introduce Dr. Payne and the staff to our only child, who was destined to complete our family. I am deeply grateful for our baby girl, who would not be with us today without Dr. Payne and the PREG Greenville staff.
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dallas dyches
1 year ago
Jun 5, 2025
What a wonderful group of people who genuinely care about us! We became pregnant on our first IVF attempt. God truly worked through the Greenville clinic!
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Chelsey Horn
1 year ago
Jun 10, 2025
When I went to a fertility clinic with an infertility diagnosis, I did not know what to expect, but I found a fertility team that was extremely thorough with testing and diagnosis. Their solutions were reassuring and encouraging and helped me keep moving forward. They truly helped me through one of the scariest times of my life. Dr. Nichols is amazing; I would not be here without him. He was honest and direct and gave us the best options. With his help and that of the wonderful nurses and staff, we are now expecting a miracle baby. I did not know if it was possible, but with their help, we succeeded. I recommend them to anyone experiencing infertility. My husband and I are deeply grateful.
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LeAnn Boswell
1 year ago
Jun 24, 2025
Dr. Payne is the best! I cannot say enough good things about the Greenville clinic. The entire staff is wonderful!
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Kayla Gladding
1 year ago
Jul 19, 2025
Dr. Payne and his nurse Tara are amazing! They are thorough and attentive in their work. Lindsay answered all my questions and offered advice. I highly recommend this excellent team. Miracles really do happen, thanks to them!
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McKinley Yang
1 year ago
Aug 3, 2025
I cannot thank PREG enough for all they have done to help support me through my fertility journey! I am now 8 weeks pregnant thanks to them and have my last ultrasound appointment with them on Monday. Madison Browning and Dr. Payne have been so great through out this entire experience and I HIGHLY recommend them for all your fertility needs :) The best part of PREG is the communication they give to their patients, I called or messaged with any questions I ever had and they almost immediately got back to me every time. They are so great here I almost wish they could be my OB lol. Also Mrs. Jackie is the best lady for your labwork, she’s hilarious and always calls for an ice pack when you need it (for my case every time).
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Calles Alfaro
1 year ago
Apr 9, 2025
I tried to make an appointment in Spanish, but no one wanted to help me. I waited 30 minutes and nothing happened. They told me to call and said they would return my call. I have been calling for three weeks. I feel discriminated against because I do not speak English. I use a translator, but they still did not want to help me schedule an appointment.
I tried to make an appointment in Spanish, but no one wanted to help me. I waited 30 minutes and nothing happened. They told me to call and said they would return my call. I have been calling for three weeks. I feel discriminated against because I do not speak English. I used a translator, but even then they did not want to help me make an appointment.
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Kathryn Henley
1 year ago
May 8, 2025
We had a wonderful experience at PREG Greenville! We appreciate the hard work of Dr. Payne, the embryologists, and our IVF coordinator, the nurses' care and compassion, and the front desk staff's patience with all our questions! We highly recommend their team to anyone experiencing infertility!
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SongBandUpstate1
2 years ago
Dec 12, 2024
I had the best experience. Dr. Nichols and the staff are second to none. They are all intelligent, kind, efficient, and not driven by profit. PREG is the only real choice in the Upstate. I am a doctor, and I know. ❤️🔥 Get to PREG as soon as possible.
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Behnaz Papari
2 years ago
Feb 23, 2025
They are a highly professional and knowledgeable team. I am a patient of Dr. Payne, and he is the best. He truly cares for his patients, listens carefully, and follows through on diagnosis so the problem can be addressed.
For a better outcome, this team truly knows what it is doing.
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DJP Costmetics
2 years ago
Mar 2, 2025
On January 29, 2025, I had an initial appointment with Dr. Nichols at the fertility clinic called PREG in West Columbia, South Carolina. I filed an assault complaint with the City of West Columbia, South Carolina, because during my examination he wore one glove to hold the ultrasound probe while his left, ungloved hand was unclean. While I was in the stirrups, he used that unclean hand and touched my clitoris while inserting the probe. He completed the examination, smelled his finger, and left the examination room with the door open. While the nurse finished the examination, my buttocks were exposed to anyone walking past.
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Kruthi Mangalampalli
1 year ago
Mar 13, 2025
Dr. John Payne is wonderful! I am extremely pleased with the staff and Dr. Payne. We highly recommend PREG :)
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Gia Valerio
1 year ago
Mar 25, 2025
They deserve negative stars. Run from this clinic! Two years ago, I saw Dr. Payne for a consultation. I was told I could never have children and needed a hysterectomy as soon as possible. He then gave me the options of using donor eggs or a surrogate. When I said those were not options for me, he replied, "If you wanted a child badly enough, you would change your mind." I do not know who in their right mind would say that to anyone. Thank God I sought a second opinion, because I am now sitting here holding my healthy one-week-old baby, conceived with my own egg. Always seek a second opinion, and never go here or believe a word Dr. Payne says. If I had listened to him, I would not have my perfect baby boy!
Local Treatment Guides
Greenville, United States IVF Clinic GuideIVF in the USA: Clinics, Costs and Success RatesPeople Also Ask
What documents are required for IVF treatment abroad? Can I choose the baby's sex with overseas IVF? What supplements are recommended when trying to conceive at an advanced maternal age? What tests should be done after trying to conceive for one year without pregnancy? Why does my ovulation test keep showing a strong positive?Free Fertility Advisor Support
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6 doctors
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Operating for many years
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PGT IVF
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Clinic Address
17 Caledon Ct # C, Greenville, SC 29615, United States
CDC Cumulative Live-Birth Rates
Data source: U.S. CDC 2022 Annual ART Report (12-month cumulative live-birth rate per intended egg retrieval; own eggs)
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Annual Total Cycles
1,807 -
U.S. Cycle Median
511
Clinic Appointment
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